Amanda Hargrove
Seminars
- Regulatory viral RNAs offer myriad new targets in diseases that impact millions of people across the world every year
- RNA-targeted small molecule libraries yield a high rate of antivirals in targeted and phenotypic screens
- Mechanism of action and target engagement are readily assessed
While splice modulation has paved the way for RNA-targeted therapeutics, the next frontier lies in unlocking the therapeutic potential of directly targeting RNA. This workshop explores innovative strategies exploring covalently binding RNA, bivalent compounds inducing proximity between RNA and effector molecules, and the untapped opportunity of targeting long non-coding RNAs.
Attendees will cover:
• Exploring covalent binders and proximity-inducing molecules to introduce functional outcomes into RNA targeted strategies
• Developing and validating a novel LC/MS-based chromatography method to quantify covalent reactivity with nucleotides/nucleobases, enabling comparison of RNA- vs protein-targeted electrophiles
• Developing lncRNA targeted small molecules to inhibit aggressive cancer phenotypes similarly to knock-out models
