Amanda Hargrove

Practical and highly interactive breakout roundtables where attendees can crowd

source solutions and share opinions around pre-assigned topic areas.

• Building RNA-focused libraries using known RNA-binding chemotypes, public datasets, chemical similarity, scaffold diversity, and RNA-relevant molecular features
• Addressing limitations of commercial screening collections by reducing reliance on protein-biased, patent-crowded, or overly familiar RNA-binding chemotypes
• Designing ML-interpretable libraries that support more efficient screening, hit clustering, SAR development, and chemical space exploration

Moderator Feedback & Audience Debate

Moderators will be assigned to each roundtable to facilitate discussion and collate

the findings. Following the roundtable discussions, they will present back to the entire

delegation and open wider audience debate

• Exploring lncRNAs as actionable targets in prostate cancer
• Targeting SChLAP1 with selective small molecule approaches
• Sharing emerging toxicity and xenograft data in vivo