Aaron Hoskins
Wasson Professor in Biochemistry University of Wisconsin-Madison
Aaron Hoskins is the Wasson Professor in Biochemistry at the University of Wisconsin–Madison, where his laboratory studies the molecular mechanisms that control eukaryotic RNA metabolism. His research focuses on the spliceosome, a large macromolecular machine responsible for removing introns from precursor mRNA, using approaches that include chemistry, biochemistry, and single-molecule fluorescence microscopy. The Hoskins Lab investigates how spliceosomes assemble, how ATP hydrolysis drives key remodeling steps, and how snRNPs are properly built and localized—processes with relevance to diseases including cancer, retinitis pigmentosa, and spinal muscular atrophy. Dr. Hoskins earned his PhD at MIT and completed postdoctoral training with Jeff Gelles and Melissa Moore.
Seminars
- Applying single-molecule and kinetic methods to characterize RNA–small moleculeminteractions in depth
- Defining the precise molecular species bound by RNA-targeting drugs to strengthen assay design and screening strategies
- Translating mechanistic insights into more informed hit identification, target engagement studies, and therapeutic development decisions