Matt Woll
Company: PTC Therapeutics
Job title: Senior Vice President of Chemistry
Seminars:
Building Mechanism-Driven Screening Platforms to Accelerate Functional Hit Discovery & Advance RNA-Targeted Drug Programs 9:00 am
• Segmenting complex RNA sequences into biologically relevant motifs to enable structure-guided screening and improve hit quality • Deploying in-house biosensors with quantitative fluorescent readouts to identify highaffinity binders and prioritize functional RNA structures • Integrating biochemical screening with cellular validation to refine structure selection and increase the likelihood of phenotypic responseRead more
day: Conference Day One
Panel Discussion Increasing Chemical Diversity in RNA-Targeted Splice Modulator Small Molecules to Expand the Target Space & Address Previously Undruggable Diseases 1:00 pm
• How can expanding the target space beyond the common splice modulators unlock new opportunities for targeting novel disease areas • What strategies are enabling the design of chemically diverse scaffolds to overcome current limitations in the ligand design space • Are we overdependent on nonsense-mediated decay and can reducing this reliance drive broaden therapeutic…Read more
day: Conference Day One