Dominic Reynolds

CSO Remix Therapeutics

This is a bio again.

Seminars

Wednesday 3rd December 2025
Panel Discussion Increasing Chemical Diversity in RNA-Targeted Splice Modulator Small Molecules to Expand the Target Space & Address Previously Undruggable Diseases
1:00 pm

• How can expanding the target space beyond the common splice modulators unlock new opportunities for targeting novel disease areas

• What strategies are enabling the design of chemically diverse scaffolds to overcome current limitations in the ligand design space

• Are we overdependent on nonsense-mediated decay and can reducing this reliance drive broaden therapeutic applicability of splice modulators

• What lessons can be drawn from recent investments and platform development to guide future innovation in RNA-targeted small molecules

Wednesday 3rd December 2025
Drugging RNA–Protein Complexes with Small Molecules to Enable RNA Splice Modulation & Degradation
9:30 am

• REM-422 is being developed by Remix Therapeutics for the treatment of ACC and AML/HRMDS

• REMaster™ platform identifies compounds that address undruggable high unmet medical need targets

• Next generation Remix drug discovery programs are enabled by a suite of biophysical assays and expand the scope of pharmacologically tractable splice modulator modalities

Tuesday 3rd December 2024
Drugging RNA–Protein Complexes with Small Molecules to Enable RNA Splice Modulation & Degradation
9:30 am
  • REM-422 is being developed by Remix Therapeutics for the treatment of ACC and AML/HRMDS
  • REMaster™ platform identifies compounds that address undruggable high unmet medical need targets
  • Next generation Remix drug discovery programs are enabled by a suite of biophysical assays and expand the scope of pharmacologically tractable splice modulator modalities
Liam Higginbottom