Amanda Hargrove
Company: University of Toronto
Job title: Professor of Chemistry
Seminars:
Emerging Modalities Beyond Splice Modulation: Harnessing Covalent Binders, Proximity-Inducing Compounds & lncRNA Targets to Discover Functional RNA Binders 1:00 pm
While splice modulation has paved the way for RNA-targeted therapeutics, the next frontier lies in unlocking the therapeutic potential of directly targeting RNA. This workshop explores innovative strategies exploring covalently binding RNA, bivalent compounds inducing proximity between RNA and effector molecules, and the untapped opportunity of targeting long non-coding RNAs. Attendees will cover: • Exploring…Read more
day: Pre Conference workshop day
Small Molecules Modulate Stability of MALAT1 Substructures 1:15 pm
• RNA-targeted libraries yield small molecule modulators of RNA conformation and function • Oncogenic MALAT1 lncRNA contains ligandable substructures with putative function • Tunable small molecules modulate MALAT1: protein interactions and lead to rapid degradationRead more
day: Conference Day Two