Amanda Hargrove
Company: University of Toronto
Job title: Professor of Chemistry
Bio:
Amanda E. Hargrove is a Canada Research Chair and Professor of Chemistry at the University of Toronto, having moved from Duke University in July 2024. Prof. Hargrove earned her Ph.D. in Organic Chemistry from the University of Texas at Austin followed by an NIH postdoctoral fellowship at the California Institute of Technology. Prof. Hargrove’s laboratory focuses on developing small molecule probes to investigate the structure and function of RNA molecules relevant to human disease. Recent honors include: the RNA Society Elisa Izaurralde Award for Innovation in Research, Teaching, and Service; the Sloan Research Fellowship; the American Chemical Society Women Chemists Committee Rising Star Award; and the Cram Lehn Pedersen Prize in Supramolecular Chemistry. Prof. Hargrove serves on the editorial advisory boards of ChemComm, Current Protocols, Medicinal Research Reviews and Supramolecular Chemistry, as a Councilor for the American Chemical Society Division of Biochemistry and Chemical Biology, and on the Board of Directors for the RNA Society and RNA Canada ARN.
Seminars:
Emerging Modalities Beyond Splice Modulation: Harnessing Covalent Binders, Proximity-Inducing Compounds & lncRNA Targets to Discover Functional RNA Binders 1:00 pm
While splice modulation has paved the way for RNA-targeted therapeutics, the next frontier lies in unlocking the therapeutic potential of directly targeting RNA. This workshop explores innovative strategies exploring covalently binding RNA, bivalent compounds inducing proximity between RNA and effector molecules, and the untapped opportunity of targeting long non-coding RNAs. Attendees will cover: • Exploring…Read more
day: Pre Conference workshop day
Identifying Viral RNA Drug Targets to Develop Novel Antivirals 1:15 pm
Regulatory viral RNAs offer myriad new targets in diseases that impact millions of people across the world every year RNA-targeted small molecule libraries yield a high rate of antivirals in targeted and phenotypic screens Mechanism of action and target engagement are readily assessedRead more
day: Conference Day Two