Evaluating How to Choose the Best Small Molecules to Achieve Desired On-Target Effects
Time: 12:15 pm
day: Pre-Conference Workshop Day
Details:
With the increasing research in small molecule-RNA targeting over the last decade and advances in machine learning, there is a growing consensus around the distinct and predictive properties that distinguish RNA-targeting small molecules from those that target proteins. It is also clear that RNAtargeting small molecules can look very similar to typical small molecule
drugs.
Many of these studies have focused purely on RNA binding, however, and
this workshop will discuss both this background and the remaining questions
and challenges in choosing the best small molecules for on-target functional
effects, such as:
- Efficiently identifying biologically active agents
- Evaluating selectivity in biological systems
- Are there binding modes and/or mechanisms of action that are particularly well-suited for functional effects?
- What lessons from covalent protein inhibitors can be applied to RNA?
