Steve Lianoglou

Company: ReviR Therapeutics

Job title: Director of Translational Genomics

Seminars:

Utilizing RNA-Seq Data At-Scale to Improve the Translatability of mRNA Splicing Modulators 11:30 am

Outlining the unique translational challenges in developing small molecule modulators of mRNA splicing Summarizing use of multi-dose RNA-seq experiments to identify potentially toxic off target liabilities for development candidates Summarizing use of multi-species RNA-seq data to improve animal model selection during preclinical researchRead more

day: Focus Day

Expert Led Breakout Session: Translating an RNA-Targeting Small Molecule from a Hit to a Human Using Novel Preclinical Modeling Strategies to Fast-Track Safe Therapeutics Towards Patients 2:00 pm

A major challenge for the translation of safe RNA targeting therapeutics is understanding RNA conservation across different animal models. Disease causing RNA sequences can change from animal to animal, therefore, new and innovative approaches need to be developed to enable reliable pre-clinical testing for accelerating safe and efficacious therapeutics towards the patients in need. During…Read more

day: Focus Day