Domi Stickens
Company: Arrakis Therapeutics Inc.
Job title: Vice President of Discovery & Translational Sciences
Bio:
Domi is Vice President of Discovery and Translational Sciences at Arrakis Therapeutics. Domi has 20 years of drug discovery and translational research experience across multiple therapeutic areas in both large pharma and small biotechs. Prior to joining Arrakis, Domi was Head of Translational Sciences at Mitobridge, which was acquired by Astellas after initiation of several clinical stage programs. Previously, Domi was at Merck, where he held increasing roles of responsibility, leading programs from early discovery to clinical development across multiple therapeutic areas. His drug discovery experience includes therapeutic areas such as autoimmune diseases and inflammation, immuno-oncology, sarcopenia, urology and hematological disorders. Domi initiated his career in healthcare during his academic research, which focused on rare diseases, principally disorders of dysregulated bone development. Connecting with patients and patient advocacy groups catalyzed a long-term passion and career commitment to the advancement of treatments for diseases with a high unmet medical need. Domi received his BS degree in Biology from Antwerp University, Belgium and his PhD in developmental genetics from UTSW Medical Center, Dallas (TX). After his thesis research, he completed a postdoctoral fellowship with Zena Werb at UCSF in San Francisco, CA.
Seminars:
Targeting Pathological RNA in Myotonic Dystrophy (DM1): Advancing a Small Molecule with Intrinsic Activity to Treat a Systemic Disease 3:45 pm
• Harnessing structure-based drug design to develop rSMs to normalize RNA splicing and relieve myotonia • Optimizing the pharmacological properties of an rSM with systemic biodistribution and functional activity in disease-relevant models • Demonstrating molecular correction and phenotypic rescue to support the translational potential of a first-in-class small molecule against DM1Read more
day: Conference Day One