Splicing: Predictive Models & Variability Between People
Time: 11:00 am
day: Day Two
Details:
- KATMAP learns a regulatory activity map for splicing factors using knockdown and in vitro RNA-binding data
- Direct regulatory target exons and associated regulatory elements are predicted
- Using GTEx RNA-seq data, we have identified tens of thousands of “naturally variable exons” (NVEs) that are spliced in some people but not others and shown that NVEs aid in interpretation of genetic variants
