Roundtable Discussion: Using RNA Recognition Principles to Build More Productive Libraries & Guide Functional Small Molecule Discovery
Practical and highly interactive breakout roundtables where attendees can crowd
source solutions and share opinions around pre-assigned topic areas.
- Building RNA-focused libraries using known RNA-binding chemotypes, public datasets, chemical similarity, scaffold diversity, and RNA-relevant molecular features
- Addressing limitations of commercial screening collections by reducing reliance on protein-biased, patent-crowded, or overly familiar RNA-binding chemotypes
- Designing ML-interpretable libraries that support more efficient screening, hit clustering, SAR development, and chemical space exploration
Moderator Feedback & Audience Debate
Moderators will be assigned to each roundtable to facilitate discussion and collate
the findings. Following the roundtable discussions, they will present back to the entire
delegation and open wider audience debate