DHX9 Inhibitors as Novel Therapeutic Modalities in MSI-High Cancers

Time: 3:00 pm
day: Day Two


  • DHX9 is an RNA helicase with important roles in replication, transcription, translation, RNA splicing and RNA processing
  • Microsatellite instable high (MSI-high) cancer cell lines are selectively dependent on DHX9 activity
  • Potent inhibitors of DHX9 have been identified that show antiproliferative activity in MSIhigh cancer models in vitro and in vivo