Comprehensive Interactome Profiling of RNA Library vs Compound Library Identifies Selective RNA Binders

Time: 9:30 am
day: Pre-Conference Focus Day


  • A highly structured RNA library that includes RNA structures identified through in-cell probing
  • In vitro interactome of ~30,000 drug-like compounds vs ~1,000 RNA structures extracted from naturally occurring RNA
  • Quantitative profiling of selectivity between RNA structures and small molecules
  • Simultaneous analysis of binding modes at the single-nucleotide resolution