Achieving Good Small Molecule Drugs by Delving into Optimal Chemical Features to Fast-Track Hit Discovery of Relevant Small Molecules
Time: 12:10 pm
day: Workshop Day
Details:
There’s currently only a small variety of small molecules which have bound to RNA and shown functional effects. Hence, there’s only a small number of relevant small molecule drugs to compare your drug discovery too. To ensure you are advancing the right small molecules, it is vital to understand what pharmacological features to look out for to ensure they can be developed into drugs later in the drug development pipeline.
This session will focus on:
- What is the pharmacology of a good small molecule drug targeting RNA?
- Identifying chemical features which make small molecules good drugs, such as understanding the ideal permeability and stickiness
- Understanding the key pharmacological properties which small molecule drugs need to enable optimization of algorithms and models
- How does a good small molecule interact with the RNA target, both in a cell and in a disease setting?
