David Sparkman-Yager
Co-Founder & Chief Technology Officer Wayfinder Biosciences
David Sparkman‑Yager, PhD is Co‑Founder & Chief Technology Officer at Wayfinder Biosciences, where he co-designed an AI‑driven platform to develop RNA‑targeting small molecules and biosensors for undruggable transcripts. Based in Seattle, he holds a PhD in molecular engineering from the University of Washington and is recognized for pioneering programmable RNA‑ligand interaction design that accelerates RNA therapeutic discovery.
Seminars
Wednesday 11th November 2026
Optimization & Functional Characterization of MYC RNA-Targeting Small Molecules
4:00 pm
- Elucidating compound mechanism by defining how mRNA-targeted MYC repression drives modulation of the MYC transcriptional network
- Demonstrating in vivo efficacy to show translation from cellular activity into disease-relevant models
- Enhancing efficacy by refining potency, exposure, and selectivity
