Roundtable Discussion: Characterizing Functionally Meaningful RNA– Protein Complexes to Enable Productive Drug Discovery
- What is the minimal RNA–protein complex that recapitulates the functional event we intend to drug – for splicing, is that the initiation/commitment step?
- How should we distinguish binding that is merely observed from engagement of a functionally meaningful fraction of the target RNA population?
- What can structural biology of the functional complex reveal about ligand recognition and the determinants of modulation that structure of the isolated RNA cannot?