Rational, Structure-Guided Design of Small Molecule Covalent Translation Inhibitors Targeting mRNA

• Identifying structured regions in mRNA as small molecule targets using cryoEM
• Using 3D information to locate small molecule binding site and understand effect of small molecule binding on RNA structure
• Dependence of translation inhibition on binding site induced proximity and proper orientation of electrophile within binding site
• Importance of using cooler electrophiles when designing covalent translation inhibitors

Speakers:

Thomas Hermann

Co-Founder, Scientific Advisor & Board Director

Syrna Therapeutics Inc