Emerging Modalities Beyond Splice Modulation: Harnessing Covalent Binders, Proximity-Inducing Compounds & lncRNA Targets to Discover Functional RNA Binders
Time: 1:00 pm
day: Pre Conference workshop day
Details:
While splice modulation has paved the way for RNA-targeted therapeutics, the next frontier lies in unlocking the therapeutic potential of directly targeting RNA. This workshop explores innovative strategies exploring covalently binding RNA, bivalent compounds inducing proximity between RNA and effector molecules, and the untapped opportunity of targeting long non-coding RNAs.
Attendees will cover:
• Exploring covalent binders and proximity-inducing molecules to introduce functional outcomes into RNA targeted strategies
• Developing and validating a novel LC/MS-based chromatography method to quantify covalent reactivity with nucleotides/nucleobases, enabling comparison of RNA- vs protein-targeted electrophiles
• Targeting long non-coding RNAs to access a vastly expanded pool of disease-relevant targets beyond the protein-coding genome
