Conformation-Driven Biochemical Screening Approach Discovers Functional RNA Binders that Modulate Myc Translation In Cancer
Time: 11:45 am
day: Conference Day Two
Details:
• Discovering selective binders for translational regulatory elements in the Myc mRNA using Wayfinder’s highly quantitative HTS platform
• Validating functional activity and drug-like properties while reaching sub-micromolar potency via compound optimization
• Elucidating compound targeting profile and tumor-specific mechanism of action
