Barak Akabayov

Barak Akabayov

Company: Ben-Gurion University of the Negev

Job title: Principal Investigator


Panel Discussion – Modelling Selectivity – Can we Develop a Model to Map Selectivity Binding? 3:45 pm

How to define selectivity and specificity? How to improve efficient and potent cell, tissue, and disease selectivity? Can we construct a suitable model for selectivity? How to guarantee selective and specific binding of your RNA targeting small molecules?Read more

day: Day Two

Expanding the Chemical Space of a Hit Molecule Obtained by Fragment Screening 1:30 pm

The development of antibiotics through rational design by pinpointing fragment molecules that bind an RNA hairpin within the ribosomal PTC and then ‘grew’ the fragment molecules computationally into drug-sized molecules with improved inhibition The use of state-of-the-art data-driven algorithms to effectively grow the fragments into drug-sized molecules The study yielded four molecules that effectively inhibited…Read more

day: Day One

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