Amanda Hargrove

Company: Duke University

Job title: Associate Professor – Chemistry

Seminars:

Modulating the Conformation & Function of Disease-Relevant RNA with Small Molecules 3:30 pm

Bioactive small molecules targeting RNA occupy a specific chemical space that can be further explored by synthesis of scaffold-based libraries Small molecule binding and degradation of the MALAT1 triple helix can be predicted via machine learning Amiloride derivatives targeting viral RNA reduce translation and replication of enteroviruses and coronavirusesRead more

day: Day One

Panel Discussion – Unravelling Methods to Delineate the Structure-Function Relationship 2:30 pm

How do we come up with methods to explore the target structure-function relationships? Can we effectively determine the mode of action of small molecules that bind to RNA and improve target engagement? How do you find the right binding pocket for there to be a functional effect and drive pharmacology to reach the therapeutic index?Read more

day: Day One