Accelerating the Discovery & Development of RNA Binders with Mass Spectrometry

Time: 11:20 am
day: Day 1 Track B AM


  • Mass spectrometry can be used to quickly identify non-covalent RNA binders using ASMS and covalent RNA binders using intact mass shift assay
  • Novel MS platforms enabling ASMS studies at <60 seconds per sample and intact mass shift assay at <15 seconds per sample are presented
  • Downstream effects of RNA binding, such as inhibition of protein expression, can be measured using proteomics LCMS workflows