Modulating the Conformation & Function of Disease-Relevant RNA with Small Molecules

Time: 3:30 pm
day: Day One


  • Bioactive small molecules targeting RNA occupy a specific chemical space that can be further explored by synthesis of scaffold-based libraries
  • Small molecule binding and degradation of the MALAT1 triple helix can be predicted via machine learning
  • Amiloride derivatives targeting viral RNA reduce translation and replication of enteroviruses and coronaviruses