Modulating the Conformation & Function of Disease-Relevant RNA with Small Molecules
Time: 3:30 pm
day: Day One
Details:
- Bioactive small molecules targeting RNA occupy a specific chemical space that can be further explored by synthesis of scaffold-based libraries
- Small molecule binding and degradation of the MALAT1 triple helix can be predicted via machine learning
- Amiloride derivatives targeting viral RNA reduce translation and replication of enteroviruses and coronaviruses
