Discovery of Novel Oncoribosome Selective Protein Translational Inhibitors via Synthetic Modified Macrolides

Time: 4:00 pm
day: Day Two


  • The TURBO-ZM platform represents an innovative leap in synthetic chemistry to generate Ribosomal Modulating Agents (RMAs) selective for the oncoribosome
  • RMAs spare normal cells while targeting a subset of cancers addicted to oncoribosome-driven protein translation
  • Proteomic analysis shows extreme susceptibility to protein translation inhibition of highly positively charged proteins that participate in translation initiation and ribogenesis